Bright Medicine Clinic

Recent Literature

Here is a selection of the best of recent research about Fecal Microbiota Transplants, in order from most recent to oldest. Click on the study names to view the study abstracts, or in some cases the full text of the papers. For an excellent overview of the safety and effectiveness of FMT for C difficile, we recommend you start with this paper: “Treating C diff Infection with Fecal Microbiota Transplantation”

Allegretti JR, Hamilton MJ, Restoring the gut microbiome for the treatment of inflammatory bowel diseases. World J Gastroenterol. 2014 Apr 7;20(13):3468-3474.
Konijeti GG et al, Cost-effectiveness of Competing Strategies for Management of Recurrent Clostridium difficile Infection: A Decision Analysis. Clin Infect Dis. 2014 Mar 31.
Lee CH et al, The outcome and long-term follow-up of 94 patients with recurrent and refractory Clostridium difficile infection using single to multiple fecal microbiota transplantation via retention enema.Eur J Clin Microbiol Infect Dis. 2014 Mar 14
Smith MB, Kelly C, Alm EJ, Policy: How to regulate faecal transplants. Nature. 2014 Feb 20;506(7488):290-1.
Udayappan SD et al, Intestinal microbiota and fecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus. Clin Exp Immunol. 2014 Feb 15.
Petrof EO et al, Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut. Microbiome. 2013 Jan 9;1(1):3
Friedman-Moraco RJ et al, Fecal microbiota transplantation for refractory Clostridium difficile colitis in solid organ transplant recipients. Am J Transplant. 2014 Feb;14(2):477-80.
Borody TJ1, Peattie D, Kapur A, Could fecal microbiota transplantation cure all Clostridium difficile infections? Future Microbiol. 2014 Jan;9(1):1-3
Zhang FM et al, Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn’s disease. World J Gastroenterol. 2013 Nov 7;19(41):7213-6
Quera R, Espinoza R, Estay C, Rivera D, Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn’s disease and recurrent Clostridium difficile infection. J Crohns Colitis. 2014 Mar;8(3):252-3.
Gutman J, Kurchin A, Split donation fecal microbiota transplantation. Am J Gastroenterol. 2013 Oct;108(10):1659-60.
Petrof EO et al., Microbial ecosystems therapeutics- a new paradigm in medicine? Benef Microbes. 2013 Mar 1;4(1):53-65.
Karlsson FH et al, Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013 May 29.
Hamilton MJ et al, High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes. 2013 Mar-Apr;4(2):125-35.
Kunde S, et al. Safety, Tolerability, and Clinical Response after Fecal Transplantation in Children and Young Adults withUlcerative Colitis. J Pediatr Gastroenterol Nutr. 2013 Mar 29.
Winter SE et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013 Feb 8;339(6120):708-11.
van Nood E et al, Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013 Jan 31;368(5):407-15. doi: 10.1056/NEJMoa1205037. Epub 2013 Jan 16.
Kronman M.P. et al., Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study.Pediatrics. 2012 Sep 24.
Anderson J.L. et al. Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease. Aliment Pharmacol Ther. 2012 Sep;36(6):503-16.
Iliev, Iliyan et al. Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis.Science. 8 June 2012: Vol. 336 no. 6086 pp. 1314-1317.
Makivuokko H, et al. Association between the ABO blood group and the human intestinal microbiota composition. BMC Microbiol. 2012 Jun 6;12(1):94.
Hamilton MJ et al, Standardized Frozen Preparation for Transplantation of Fecal Microbiota for Recurrent Clostridium difficile Infection. The American Journal of Gastroenterology 107, 761-767 May 2012.
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Mehrabani D. et al. The Effect of Calendula Officinalis in Therapy of Acetic Acid Induced Ulcerative Colitis in Dog as an Animal Model. Iran Red Crescent Med J. 2011 December; 13(12): 884–890.
Bakken, JC et al. for the Fecal Microbiota Transplantation Workgroup. Treating Clostridium difficile Infection With Fecal Microbiota Transplantation. Clinical Gastroenterology and Hepatology. December 2011.
Borody TJ, Campbell J. Fecal microbiota transplantation: current status and future directions.Expert Rev Gastroenterol Hepatol. 2011 Dec;5(6):653-5.
Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis. 2011 Nov;53(10):994-1002.
Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011 Oct 26.
Blaser, M. Antibiotic overuse- Stop the killing of beneficial bacteria. Nature. 2011 Aug 24;476(7361)-393-4..doc
Khoruts, A and Sadowsky, MJ. Therapeutic transplantation of the distal gut microbiota. Mucosal Immunol. 2011 Jan;4(1):4-7.
Ananthaswamy A. Faecal transplant eases symptoms of Parkinson’s. New Scientist. 19 Jan 2011.
Manichanh C et al. Reshaping the gut microbiome with bacterial transplantation and antibiotic intake. Genome Res. 2010 Oct;20(10):1411-9. Epub 2010 Aug 24.
Grehan, MJ et al. Durable Alteration of the Colonic Microbiota by the Administration of Donor Fecal Flora. J Clin Gastroenterol. 2010 September; 44(8);551-561.
Silverman MS, Davis I, Pillai DR. Success of self-administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gastroenterol Hepatol. 2010 May;8(5):471-3.
Vrieze, A et al. The environment within: how gut microbiota may influence metabolism and body composition.Diabetologia. 2010 April; 53(4): 606–613.
Turnbaugh PJ, Gordon JI. The core gut microbiome, energy balance and obesity. J Physiol. 2009 Sep 1;587(Pt 17):4153-8.
Sokol, H et al. Low Counts of Faecalibacterium prausnitzii in Colitis Microbiota. Inflamm Bowel Dis. 2009 Aug;15(8):1183-9.
Bakken JS. Fecal bacteriotherapy for recurrent Clostridium difficile infection. Anaerobe. 2009;15:285–289
Swidsinski A et al, Bacterial biofilm suppression with antibiotics for ulcerative and indeterminate colitis: consequences of aggressive treatment. Arch Med Res. 2008 Feb;39(2):198-204. doi: 10.1016/j.arcmed.2007.08.001. Epub 2007 Oct 31.
Swidsinski A et al, Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol. 2005 Jul;43(7):3380-9.
Borody TJ, Warren EF, Leis SM, et al. Bacteriotherapy using fecal flora: toying with human motions. J Clin Gastroenterol. 2004;38:475–483
Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7